The article presents the basic concepts through which the psychological modes of social adaptation of students with disabilities to educational activities are revealed, namely communicative, activity, psychosomatic, asthenic. The study sample consisted of 26 students with disabilities and/or health limited activities of the 1st, 2nd and 3rd courses of Tver State Medical University. During the interpretation of the results of the study, it was revealed that the majority of respondents had a low level of adaptive capabilities according to the data obtained, the vast majority of students experience difficulties in the field of social interaction. In this regard, the importance of implementing measures and measures for the psychological and pedagogical support of students with disabilities and/or health limited activities in a medical university is emphasized.